Published on May 9, 2018
CBD Overview: Benefits Explained & How it Works in the Body – Thomas DeLauer
CBD 1 & 2 Receptors
Inside the human body there’s the endocannabinoid system*, with receptors spread throughout the brain and body
*biological system of endocannabinoids, which are neurotransmitters that bind to cannabinoid receptors, and cannabinoid receptor proteins throughout the central nervous system*
The human body has two receptors for cannabinoids, called CB1 receptors and CB2 receptors
CB1 receptors are found all around the body, but many of them are in the brain.
The CB1 receptors in the brain deal with coordination and movement, pain, emotions and mood, thinking, appetite, and memories, among others – THC attaches to these receptors.
CB2 receptors are more common in the immune system – they affect inflammation and pain
THC activates the CB1 and CB2 receptors, while CBD does not directly stimulate these receptors
It used to be thought that CBD acts on CB2 receptors, but it appears that CBD does not act on either receptor directly – instead, it seems to influence the body to use more of its own cannabinoids
How it Works in the Body/Benefits
CBD does not stimulate these two receptors – instead, it activates other receptors, like the vanilloid, adenosine and serotonin receptors
By activating the TRPV1 (also known as capsaicin receptor and the vanilloid receptor 1) receptor for example, CBD plays a role in the mediation of body temperature, pain perception and inflammation
CBD also inhibits the FAAH enzyme, a compound that activates the CB1 receptor – by doing so, CBD minimizes the activation of CB1 by THC, reducing its psychoactive effects
The activation of adenosine receptors by CBD gives the anti-anxiety and anti-inflammatory effects of cannabidiol – adenosine receptors are also involved in the release of dopamine and glutamate, two neurotransmitters that play major roles inside the body
Dopamine & Glutamate
Dopamine is involved in cognition, motor control, motivation and reward mechanisms, while glutamate is one of the major mediators of excitatory signals, being involved in memory, learning and cognition
High concentrations of CBD have been shown to activate the 5-HT1A serotonin receptor, exerting anti-depressant effects – the same receptor is involved in a series of processes from pain perception, appetite, nausea and anxiety to sleep and addiction mechanisms
Finally, CBD blocks GPR55 signaling, decreasing bone reabsorption and cancer cell proliferation – GPR55 is widely present inside the brain, being linked with the modulation of bone density and blood pressure, as well as with cancer cell proliferation.
I’ll see you next time,
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